Version 5.4
Bos taurus Protein: HIF1AN
Summary
InnateDB Protein IDBP-690884.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIF1AN
Protein Name hypoxia-inducible factor 1-alpha inhibitor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000101
InnateDB Gene IDBG-638788 (HIF1AN)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005112 Notch binding
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031406 carboxylic acid binding
GO:0036139 peptidyl-histidine dioxygenase activity
GO:0036140 peptidyl-asparagine 3-dioxygenase activity
GO:0042803 protein homodimerization activity
GO:0048037 cofactor binding
GO:0051059 NF-kappaB binding
GO:0071532 ankyrin repeat binding
Biological Process
GO:0036138 peptidyl-histidine hydroxylation
GO:0042264 peptidyl-aspartic acid hydroxylation
GO:0042265 peptidyl-asparagine hydroxylation
GO:0045663 positive regulation of myoblast differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0055114 oxidation-reduction process
GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003347 JmjC domain
PFAM PF02373
PF08007
PRINTS
PIRSF
SMART SM00558
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MG82
UniProt Splice Variant
Entrez Gene 520864
UniGene
RefSeq NP_001076912
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02058970
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca