InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GNGT2

Summary

InnateDB Protein

IDBP-690927.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNGT2

Protein Name

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000054464

InnateDB Gene

IDBG-638827 (GNGT2)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway

Cellular Component

GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001770 G-protein, gamma subunit
IPR015898 G-protein gamma-like domain

PFAM

PF00631

PRINTS

PR00321

PIRSF

SMART

SM00224

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P50154

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281797

UniGene

Bt.1263

RefSeq

NP_776753

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC147970 U20085

GenPept

AAB61306 AAI47971