InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DTD1

Summary

InnateDB Protein

IDBP-690961.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DTD1

Protein Name

D-tyrosyl-tRNA(Tyr) deacylase 1

Synonyms

DUE-B;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011800

InnateDB Gene

IDBG-638861 (DTD1)

Protein Structure

UniProt Annotation

Function

ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D- tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful effect of D-tyrosine (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000305}. Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0016787	hydrolase activity
GO:0016788	hydrolase activity, acting on ester bonds
GO:0046872	metal ion binding

Biological Process

GO:0006260	DNA replication
GO:0019478	D-amino acid catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR003732 D-tyrosyl-tRNA(Tyr) deacylase
IPR023509 D-Tyr tRNAtyr deacylase-like domain

PFAM

PF02580

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2T9V8

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

514493

UniGene

Bt.64605

RefSeq

NP_001033193

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC111244

GenPept

AAI11245