InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.25271

Summary

InnateDB Protein

IDBP-690982.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.25271

Protein Name

F-box/WD repeat-containing protein 1A

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000009830

InnateDB Gene

IDBG-638879 (BT.25271)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 158 interaction(s) predicted by orthology.

Predicted by orthology
Total	158 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0045309	protein phosphorylated amino acid binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0006470	protein dephosphorylation
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0030163	protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648	protein destabilization
GO:0033598	mammary gland epithelial cell proliferation
GO:0042752	regulation of circadian rhythm
GO:0042753	positive regulation of circadian rhythm
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045862	positive regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051726	regulation of cell cycle
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0061136	regulation of proteasomal protein catabolic process
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0019005

SCF ubiquitin ligase complex

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR001810 F-box domain
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
IPR021977 D domain of beta-TrCP

PFAM

PF00400
PF00646
PF12937
PF13013
PF12125

PRINTS

PR00320

PIRSF

SMART

SM00320
SM00256
SM01028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt