Version 5.4
Bos taurus Protein: NFE2L1
Summary
InnateDB Protein IDBP-691058.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFE2L1
Protein Name Nuclear factor erythroid 2-related factor 1
Synonyms NRF1;
Species Bos taurus
Ensembl Protein ENSBTAP00000018147
InnateDB Gene IDBG-638948 (NFE2L1)
Protein Structure
UniProt Annotation
Function Activates erythroid-specific, globin gene expression. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein. Nucleus {ECO:0000255PROSITE-ProRule:PRU00978}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0030218 erythrocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
PFAM PF00170
PF07716
PRINTS
PIRSF
SMART SM00338
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A5D7E9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 534582
UniGene Bt.28567
RefSeq NP_001095985
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140530
GenPept AAI40531

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca