InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GEMIN8

Summary

InnateDB Protein

IDBP-691087.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GEMIN8

Protein Name

Gem-associated protein 8

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013582

InnateDB Gene

IDBG-638978 (GEMIN8)

Protein Structure

UniProt Annotation

Function

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, gem {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0032797	SMN complex
GO:0034719	SMN-Sm protein complex
GO:0097504	Gemini of coiled bodies

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1LZ79

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

515968

UniGene

Bt.2768

RefSeq

NP_001069199

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC116157

GenPept

AAI16158