InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EIF3C

Summary

InnateDB Protein

IDBP-691218.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF3C

Protein Name

Eukaryotic translation initiation factor 3 subunit C

Synonyms

eIF3-p110; EIF3C; EIF3S8;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023384

InnateDB Gene

IDBG-639085 (EIF3C)

Protein Structure

UniProt Annotation

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. {ECO:0000255HAMAP- Rule:MF_03002}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03002}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.

Predicted by orthology
Total	70 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0031369	translation initiation factor binding

Biological Process

GO:0001731	formation of translation preinitiation complex
GO:0006412	translation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation

Cellular Component

GO:0005737	cytoplasm
GO:0005852	eukaryotic translation initiation factor 3 complex
GO:0016282	eukaryotic 43S preinitiation complex
GO:0033290	eukaryotic 48S preinitiation complex
GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m

Protein Structure and Domains

PDB ID

InterPro

IPR000717 Proteasome component (PCI) domain
IPR008905 Eukaryotic translation initiation factor 3 subunit C, N-terminal domain

PFAM

PF01399
PF05470

PRINTS

PIRSF

SMART

SM00088

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3SYW6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

534882

UniGene

Bt.2516

RefSeq

NP_001029790

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103352

GenPept

AAI03353