Version 5.4
Bos taurus Protein: CLN3
Summary
InnateDB Protein IDBP-691228.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLN3
Protein Name ceroid-lipofuscinosis, neuronal 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000023952
InnateDB Gene IDBG-639101 (CLN3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0000046 autophagic vacuole fusion
GO:0001508 action potential
GO:0006520 cellular amino acid metabolic process
GO:0006865 amino acid transport
GO:0007034 vacuolar transport
GO:0007040 lysosome organization
GO:0007042 lysosomal lumen acidification
GO:0008306 associative learning
GO:0015809 arginine transport
GO:0016236 macroautophagy
GO:0016242 negative regulation of macroautophagy
GO:0016485 protein processing
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0042133 neurotransmitter metabolic process
GO:0043086 negative regulation of catalytic activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0045861 negative regulation of proteolysis
GO:0050885 neuromuscular process controlling balance
GO:0051480 cytosolic calcium ion homeostasis
GO:0061024 membrane organization
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005776 autophagic vacuole
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031301 integral component of organelle membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR003492 Batten\'s disease protein Cln3
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR018460 Batten\'s disease protein Cln3, subgroup
PFAM PF02487
PRINTS PR01315
PIRSF PIRSF015974
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MX24
UniProt Splice Variant
Entrez Gene 504799
UniGene
RefSeq NP_001068642
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057887
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca