Version 5.4
Bos taurus Protein: SLX1A
Summary
InnateDB Protein IDBP-691285.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLX1A
Protein Name Structure-specific endonuclease subunit SLX1
Synonyms GIYD; GIYD1;
Species Bos taurus
Ensembl Protein ENSBTAP00000011384
InnateDB Gene IDBG-639151 (SLX1A)
Protein Structure
UniProt Annotation
Function Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. {ECO:0000255HAMAP-Rule:MF_03100}.
Subcellular Localization Nucleus {ECO:0000255HAMAP-Rule:MF_03100}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0008821 crossover junction endodeoxyribonuclease activity
GO:0016787 hydrolase activity
GO:0017108 5'-flap endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0033557 Slx1-Slx4 complex
Protein Structure and Domains
PDB ID
InterPro IPR000305 GIY-YIG nuclease superfamily
IPR011011 Zinc finger, FYVE/PHD-type
PFAM PF01541
PRINTS
PIRSF
SMART SM00465
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32PI0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510858
UniGene Bt.62766
RefSeq NP_001032533
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC108108
GenPept AAI08109

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca