InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ARL3

Summary

InnateDB Protein

IDBP-691371.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARL3

Protein Name

ADP-ribosylation factor-like protein 3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005655

InnateDB Gene

IDBG-639231 (ARL3)

Protein Structure

UniProt Annotation

Function

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Note=Detected predominantly in the photoreceptor connecting cilium. Present on the mitotic spindle. Centrosome- associated throughout the cell cycle. Not detected to interphase microtubules (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008017	microtubule binding
GO:0019001	guanyl nucleotide binding
GO:0019003	GDP binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0000910	cytokinesis
GO:0001822	kidney development
GO:0006184	GTP catabolic process
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0007049	cell cycle
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007224	smoothened signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0042073	intraciliary transport
GO:0042461	photoreceptor cell development
GO:0051301	cell division
GO:0060271	cilium morphogenesis

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005856	cytoskeleton
GO:0005876	spindle microtubule
GO:0005881	cytoplasmic microtubule
GO:0005929	cilium
GO:0016020	membrane
GO:0030496	midbody
GO:0032391	photoreceptor connecting cilium
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome
GO:0072372	primary cilium

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM