Version 5.4
Bos taurus Protein: BCL3
Summary
InnateDB Protein IDBP-691407.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL3
Protein Name B-cell CLL/lymphoma 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012490
InnateDB Gene IDBG-639255 (BCL3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0002268 follicular dendritic cell differentiation
GO:0002315 marginal zone B cell differentiation
GO:0002455 humoral immune response mediated by circulating immunoglobulin
GO:0002467 germinal center formation
GO:0006351 transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0009615 response to virus
GO:0010225 response to UV-C
GO:0019730 antimicrobial humoral response
GO:0030198 extracellular matrix organization
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0032729 positive regulation of interferon-gamma production
GO:0042088 T-helper 1 type immune response
GO:0042345 regulation of NF-kappaB import into nucleus
GO:0042536 negative regulation of tumor necrosis factor biosynthetic process
GO:0042742 defense response to bacterium
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042832 defense response to protozoan
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045064 T-helper 2 cell differentiation
GO:0045082 positive regulation of interleukin-10 biosynthetic process
GO:0045415 negative regulation of interleukin-8 biosynthetic process
GO:0045727 positive regulation of translation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048536 spleen development
GO:0051101 regulation of DNA binding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0032996 Bcl3-Bcl10 complex
GO:0033257 Bcl3/NF-kappaB2 complex
GO:0043234 protein complex
GO:0045171 intercellular bridge
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BCE6
UniProt Splice Variant
Entrez Gene 531942
UniGene Bt.16930
RefSeq NP_001192922
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02047337
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca