Version 5.4
Bos taurus Protein: NT5C2
Summary
InnateDB Protein IDBP-691428.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NT5C2
Protein Name Cytosolic purine 5'-nucleotidase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017090
InnateDB Gene IDBG-639281 (NT5C2)
Protein Structure
UniProt Annotation
Function May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. {ECO:0000269PubMed:9371705}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008253 5'-nucleotidase activity
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
GO:0009117 nucleotide metabolic process
GO:0016311 dephosphorylation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008380 HAD-superfamily hydrolase, subfamily IG, 5\'-nucleotidase
IPR016695 Purine 5\'-nucleotidase
IPR023214 HAD-like domain
PFAM PF05761
PF00702
PF08282
PF13419
PRINTS
PIRSF PIRSF017434
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O46411
PhosphoSite PhosphoSite-
TrEMBL B1H0W4
UniProt Splice Variant
Entrez Gene 281951
UniGene Bt.5382
RefSeq NP_776830
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151380 U73690
GenPept AAC48784 AAI51381

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca