InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP27

Summary

InnateDB Protein

IDBP-69144.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP27

Protein Name

matrix metallopeptidase 27

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000260229

InnateDB Gene

IDBG-69142 (MMP27)

Protein Structure

UniProt Annotation

Function

Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens. {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in B-cells. {ECO:0000269PubMed:14506071}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0030574	collagen catabolic process

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References