Version 5.4
Bos taurus Protein: APOE
Summary
InnateDB Protein IDBP-691450.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOE
Protein Name apolipoprotein E precursor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013354
InnateDB Gene IDBG-639311 (APOE)
Protein Structure
UniProt Annotation
Function Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005319 lipid transporter activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008201 heparin binding
GO:0008289 lipid binding
GO:0016209 antioxidant activity
GO:0017127 cholesterol transporter activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046911 metal chelating activity
GO:0048156 tau protein binding
GO:0050750 low-density lipoprotein particle receptor binding
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070326 very-low-density lipoprotein particle receptor binding
GO:0071813 lipoprotein particle binding
Biological Process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002021 response to dietary excess
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0006707 cholesterol catabolic process
GO:0006810 transport
GO:0006869 lipid transport
GO:0006874 cellular calcium ion homeostasis
GO:0006898 receptor-mediated endocytosis
GO:0006979 response to oxidative stress
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007263 nitric oxide mediated signal transduction
GO:0008203 cholesterol metabolic process
GO:0010468 regulation of gene expression
GO:0010544 negative regulation of platelet activation
GO:0010873 positive regulation of cholesterol esterification
GO:0010875 positive regulation of cholesterol efflux
GO:0015909 long-chain fatty acid transport
GO:0017038 protein import
GO:0019934 cGMP-mediated signaling
GO:0030195 negative regulation of blood coagulation
GO:0030828 positive regulation of cGMP biosynthetic process
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0034374 low-density lipoprotein particle remodeling
GO:0034375 high-density lipoprotein particle remodeling
GO:0034380 high-density lipoprotein particle assembly
GO:0034382 chylomicron remnant clearance
GO:0034384 high-density lipoprotein particle clearance
GO:0034447 very-low-density lipoprotein particle clearance
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042159 lipoprotein catabolic process
GO:0042311 vasodilation
GO:0042632 cholesterol homeostasis
GO:0043407 negative regulation of MAP kinase activity
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043691 reverse cholesterol transport
GO:0045541 negative regulation of cholesterol biosynthetic process
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048844 artery morphogenesis
GO:0050728 negative regulation of inflammatory response
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051055 negative regulation of lipid biosynthetic process
GO:0051651 maintenance of location in cell
GO:0055088 lipid homeostasis
GO:0055089 fatty acid homeostasis
GO:0060999 positive regulation of dendritic spine development
GO:0061000 negative regulation of dendritic spine development
GO:0072358 cardiovascular system development
GO:0090370 negative regulation of cholesterol efflux
GO:0097113 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097114 N-methyl-D-aspartate receptor clustering
GO:1900221 regulation of beta-amyloid clearance
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901627 negative regulation of postsynaptic membrane organization
GO:1901628 positive regulation of postsynaptic membrane organization
GO:1901630 negative regulation of presynaptic membrane organization
GO:1901631 positive regulation of presynaptic membrane organization
GO:1902004 positive regulation of beta-amyloid formation
GO:1902430 negative regulation of beta-amyloid formation
GO:1902947 regulation of tau-protein kinase activity
GO:1902951 negative regulation of dendritic spine maintenance
GO:1902952 positive regulation of dendritic spine maintenance
GO:1902995 positive regulation of phospholipid efflux
GO:1902998 positive regulation of neurofibrillary tangle assembly
GO:1902999 negative regulation of phospholipid efflux
GO:1903001 negative regulation of lipid transport across blood brain barrier
GO:1903002 positive regulation of lipid transport across blood brain barrier
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0016020 membrane
GO:0034361 very-low-density lipoprotein particle
GO:0034362 low-density lipoprotein particle
GO:0034363 intermediate-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0042627 chylomicron
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR000074 Apolipoprotein A1/A4/E
PFAM PF01442
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q03247
PhosphoSite PhosphoSite-
TrEMBL Q0ZCB4
UniProt Splice Variant
Entrez Gene 281004
UniGene
RefSeq NP_776416
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102620 BT021053 DQ538523 X61171 X64839
GenPept AAI02621 AAX09070 ABG56137 CAA43479 CAA46051

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca