InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: OBFC1

Summary

InnateDB Protein

IDBP-691520.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OBFC1

Protein Name

CST complex subunit STN1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000019995

InnateDB Gene

IDBG-639369 (OBFC1)

Protein Structure

UniProt Annotation

Function

Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0043047	single-stranded telomeric DNA binding

Biological Process

GO:0000723	telomere maintenance
GO:0010833	telomere maintenance via telomere lengthening
GO:0045740	positive regulation of DNA replication

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005730	nucleolus
GO:0043231	intracellular membrane-bounded organelle
GO:0045111	intermediate filament cytoskeleton
GO:0070188	Stn1-Ten1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
IPR012340 Nucleic acid-binding, OB-fold
IPR014647 CST complex subunit Stn1
IPR015253 CST complex subunit Stn1, C-terminal

PFAM

PF01336
PF09170

PRINTS

PIRSF

PIRSF036950

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08DB2