InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MED1

Summary

InnateDB Protein

IDBP-691523.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED1

Protein Name

mediator complex subunit 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053186

InnateDB Gene

IDBG-639352 (MED1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.

Predicted by orthology
Total	105 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001047	core promoter binding
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0030331	estrogen receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0030375	thyroid hormone receptor coactivator activity
GO:0032403	protein complex binding
GO:0035257	nuclear hormone receptor binding
GO:0036033	mediator complex binding
GO:0042974	retinoic acid receptor binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:0046966	thyroid hormone receptor binding
GO:0050693	LBD domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000902	cell morphogenesis
GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0002088	lens development in camera-type eye
GO:0002154	thyroid hormone mediated signaling pathway
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0003406	retinal pigment epithelium development
GO:0006356	regulation of transcription from RNA polymerase I promoter
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006590	thyroid hormone generation
GO:0006702	androgen biosynthetic process
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0007507	heart development
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0010628	positive regulation of gene expression
GO:0010839	negative regulation of keratinocyte proliferation
GO:0030216	keratinocyte differentiation
GO:0030224	monocyte differentiation
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0031100	organ regeneration
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0033598	mammary gland epithelial cell proliferation
GO:0033601	positive regulation of mammary gland epithelial cell proliferation
GO:0035050	embryonic heart tube development
GO:0035116	embryonic hindlimb morphogenesis
GO:0035162	embryonic hemopoiesis
GO:0035357	peroxisome proliferator activated receptor signaling pathway
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0035855	megakaryocyte development
GO:0042789	mRNA transcription from RNA polymerase II promoter
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0045444	fat cell differentiation
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048821	erythrocyte development
GO:0048822	enucleate erythrocyte development
GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway
GO:0060744	mammary gland branching involved in thelarche
GO:0060745	mammary gland branching involved in pregnancy
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation
GO:0070318	positive regulation of G0 to G1 transition
GO:0070371	ERK1 and ERK2 cascade
GO:0070562	regulation of vitamin D receptor signaling pathway
GO:0071364	cellular response to epidermal growth factor stimulus
GO:0071383	cellular response to steroid hormone stimulus
GO:0097067	cellular response to thyroid hormone stimulus
GO:2000273	positive regulation of receptor activity
GO:2000347	positive regulation of hepatocyte proliferation
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane
GO:0016592	mediator complex

Protein Structure and Domains

PDB ID

InterPro

IPR019680 Mediator complex, subunit Med1, metazoa/fungi

PFAM

PF10744

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E1B7Q6

UniProt Splice Variant

Entrez Gene

520734

UniGene

Bt.64864

RefSeq

NP_001192805

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02049117

GenPept