Version 5.4
Bos taurus Protein: TCAP
Summary
InnateDB Protein IDBP-691543.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCAP
Protein Name Telethonin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015579
InnateDB Gene IDBG-639393 (TCAP)
Protein Structure
UniProt Annotation
Function Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, myofibril, sarcomere {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0030674 protein binding, bridging
GO:0031432 titin binding
GO:0044325 ion channel binding
GO:0051373 FATZ binding
GO:0070080 titin Z domain binding
Biological Process
GO:0001756 somitogenesis
GO:0003009 skeletal muscle contraction
GO:0003300 cardiac muscle hypertrophy
GO:0007512 adult heart development
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0030240 skeletal muscle thin filament assembly
GO:0030241 skeletal muscle myosin thick filament assembly
GO:0030916 otic vesicle formation
GO:0035995 detection of muscle stretch
GO:0048739 cardiac muscle fiber development
GO:0048769 sarcomerogenesis
GO:0055003 cardiac myofibril assembly
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005737 cytoplasm
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0031674 I band
Protein Structure and Domains
PDB ID
InterPro IPR015667 Telethonin
PFAM PF09470
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6T8D8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 513257
UniGene Bt.88348
RefSeq NP_001014915
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY428575 BC103048 BC142094
GenPept AAI03049 AAI42095 AAR11378

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca