InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PHKG2

Summary

InnateDB Protein

IDBP-691601.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHKG2

Protein Name

Phosphorylase b kinase gamma catalytic chain, testis/liver isoform

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004433

InnateDB Gene

IDBG-639436 (PHKG2)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004689	phosphorylase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005977	glycogen metabolic process
GO:0005978	glycogen biosynthetic process
GO:0006468	protein phosphorylation
GO:0016310	phosphorylation

Cellular Component

GO:0005964

phosphorylase kinase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR002291 Phosphorylase kinase, gamma catalytic subunit
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109
PR01049

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KJ16

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

512670

UniGene

Bt.11190

RefSeq

NP_001039593

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC105568 BT030706

GenPept

AAI05569 ABS45022