InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MSTN

Summary

InnateDB Protein

IDBP-691622.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MSTN

Protein Name

Growth/differentiation factor 8

Synonyms

GDF8;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015674

InnateDB Gene

IDBG-639462 (MSTN)

Protein Structure

UniProt Annotation

Function

Acts specifically as a negative regulator of skeletal muscle growth.

Subcellular Localization

Secreted.

Disease Associations

Note=Defects in MSTN are the cause of the double-muscle phenotype or muscular hypertrophy (mh), an autosomal recessive disease frequently found in the Belgian blue and Piedmontese cattle breeds. This disease is characterized by an increased number of muscle fibers (hyperplasia), resulting in an increase in muscle mass of 20-25%.

Tissue Specificity

Specifically expressed in developing and adult skeletal muscle. Highest levels found in the hindlimb semimembranosus and biceps-femoris muscles; low levels in other hindlimb muscles.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0042802	identical protein binding

Biological Process

GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0040007	growth
GO:0045893	positive regulation of transcription, DNA-templated
GO:0071549	cellular response to dexamethasone stimulus