InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ERBB2

Summary

InnateDB Protein

IDBP-691624.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERBB2

Protein Name

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000029056

InnateDB Gene

IDBG-639410 (ERBB2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 152 interaction(s) predicted by orthology.

Predicted by orthology
Total	152 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001042	RNA polymerase I core binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004716	receptor signaling protein tyrosine kinase activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0019903	protein phosphatase binding
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399	nervous system development
GO:0007422	peripheral nervous system development
GO:0007507	heart development
GO:0007528	neuromuscular junction development
GO:0008045	motor neuron axon guidance
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0016310	phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030307	positive regulation of cell growth
GO:0032321	positive regulation of Rho GTPase activity
GO:0032886	regulation of microtubule-based process
GO:0033088	negative regulation of immature T cell proliferation in thymus
GO:0042060	wound healing
GO:0042552	myelination
GO:0043406	positive regulation of MAP kinase activity
GO:0045727	positive regulation of translation
GO:0045785	positive regulation of cell adhesion
GO:0045943	positive regulation of transcription from RNA polymerase I promoter
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0046777	protein autophosphorylation
GO:0048709	oligodendrocyte differentiation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0070372	regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000494 EGF receptor, L domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR006211 Furin-like cysteine-rich domain
IPR006212 Furin-like repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01030
PF00069
PF07714
PF00757

PRINTS

PR00109

PIRSF

PIRSF000619

SMART

SM00220
SM00261
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References