Version 5.4
Bos taurus Protein: MIEN1
Summary
InnateDB Protein IDBP-691630.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MIEN1
Protein Name Protein C17orf37 homolog
Synonyms C17orf37; C19H17orf37;
Species Bos taurus
Ensembl Protein ENSBTAP00000029060
InnateDB Gene IDBG-639468 (MIEN1)
Protein Structure
UniProt Annotation
Function Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008430 selenium binding
Biological Process
GO:0006915 apoptotic process
GO:0030335 positive regulation of cell migration
GO:0043066 negative regulation of apoptotic process
GO:0045454 cell redox homeostasis
GO:0051491 positive regulation of filopodium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR011893 Selenoprotein, Rdx type
IPR012336 Thioredoxin-like fold
PFAM PF10262
PF13098
PF13192
PF13462
PF13905
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q148C8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505710
UniGene Bt.17107
RefSeq NP_001068689
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118463
GenPept AAI18464

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca