InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP8

Summary

InnateDB Protein

IDBP-69166.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP8

Protein Name

matrix metallopeptidase 8 (neutrophil collagenase)

Synonyms

CLG1; HNC; MMP-8; PMNL-CL;

Species

Homo sapiens

Ensembl Protein

ENSP00000236826

InnateDB Gene

IDBG-69164 (MMP8)

Protein Structure

UniProt Annotation

Function

Can degrade fibrillar type I, II, and III collagens.

Subcellular Localization

Cytoplasmic granule. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Note=Stored in intracellular granules.

Disease Associations

Tissue Specificity

Neutrophils.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0045087	innate immune response

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000585 Hemopexin-like domain
IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR006026 Peptidase, metallopeptidase
IPR016293 Peptidase M10A, stromelysin-type
IPR018487 Hemopexin-like repeats
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471
PF00045

PRINTS

PR00138

PIRSF

PIRSF001191

SMART

SM00235
SM00120

TIGRFAMs

Post-translational Modifications

Modification

Cross-References