Version 5.4
Bos taurus Protein: ORMDL3
Summary
InnateDB Protein IDBP-691673.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORMDL3
Protein Name ORM1-like protein 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000018402
InnateDB Gene IDBG-639509 (ORMDL3)
Protein Structure
UniProt Annotation
Function Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006672 ceramide metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0035339 SPOTS complex
Protein Structure and Domains
PDB ID
InterPro IPR007203 ORMDL
PFAM PF04061
PRINTS
PIRSF PIRSF018147
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VD15
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 615368
UniGene Bt.4613
RefSeq NP_001069835
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119888
GenPept AAI19889

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca