Version 5.4
Bos taurus Protein: STX4
Summary
InnateDB Protein IDBP-691691.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STX4
Protein Name Syntaxin-4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009899
InnateDB Gene IDBG-639524 (STX4)
Protein Structure
UniProt Annotation
Function Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. May also play a role in docking of synaptic vesicles at presynaptic active zones (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006836 neurotransmitter transport
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
GO:0035493 SNARE complex assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0031201 SNARE complex
GO:0035749 myelin sheath adaxonal region
GO:0042581 specific granule
GO:0043219 lateral loop
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000727 Target SNARE coiled-coil domain
IPR006011 Syntaxin, N-terminal domain
IPR010989 t-SNARE
PFAM PF05739
PF00804
PRINTS
PIRSF
SMART SM00397
SM00503
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SWZ3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508675
UniGene Bt.65883
RefSeq NP_001030236
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104588
GenPept AAI04589

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca