Version 5.4
Bos taurus Protein: CSF3
Summary
InnateDB Protein IDBP-691692.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSF3
Protein Name Granulocyte colony-stimulating factor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028610
InnateDB Gene IDBG-639529 (CSF3)
Protein Structure
UniProt Annotation
Function Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0019899 enzyme binding
Biological Process
GO:0006955 immune response
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030838 positive regulation of actin filament polymerization
GO:0032092 positive regulation of protein binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0071345 cellular response to cytokine stimulus
GO:2000251 positive regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR003573 Interleukin-6/Interleukin-23/GCSF/MGF
IPR009079 Four-helical cytokine-like, core
PFAM PF00489
PRINTS PR00433
PIRSF PIRSF001935
SMART SM00126
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P35833
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281096
UniGene Bt.4660
RefSeq NP_776453
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF092533
GenPept AAD16102

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca