InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: VASP

Summary

InnateDB Protein

IDBP-691722.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VASP

Protein Name

Vasodilator-stimulated phosphoprotein

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026119

InnateDB Gene

IDBG-639546 (VASP)

Protein Structure

UniProt Annotation

Function

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin- bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}. Cell projection, filopodium membrane {ECO:0000250}. Note=Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0017124	SH3 domain binding

Biological Process

GO:0001843	neural tube closure
GO:0007411	axon guidance
GO:0008154	actin polymerization or depolymerization
GO:0030036	actin cytoskeleton organization
GO:0030838	positive regulation of actin filament polymerization
GO:0051289	protein homotetramerization

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030175	filopodium
GO:0031258	lamellipodium membrane
GO:0031527	filopodium membrane
GO:0042995	cell projection
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000697 WH1/EVH1
IPR014885 VASP tetramerisation
IPR017354 Vasodilator-stimulated phosphoprotein

PFAM

PF00568
PF08776

PRINTS

PIRSF

PIRSF038010

SMART

SM00461

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2TA49

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

514902

UniGene

Bt.56013

RefSeq

NP_001033199

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC111116

GenPept

AAI11117