Version 5.4
Bos taurus Protein: PYCARD
Summary
InnateDB Protein IDBP-691750.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PYCARD
Protein Name apoptosis-associated speck-like protein containing a CARD
Synonyms ASC;
Species Bos taurus
Ensembl Protein ENSBTAP00000027359
InnateDB Gene IDBG-639579 (PYCARD)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002218 activation of innate immune response
GO:0002230 positive regulation of defense response to virus by host
GO:0002277 myeloid dendritic cell activation involved in immune response
GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0030838 positive regulation of actin filament polymerization
GO:0031647 regulation of protein stability
GO:0032314 regulation of Rac GTPase activity
GO:0032611 interleukin-1 beta production
GO:0032729 positive regulation of interferon-gamma production
GO:0032755 positive regulation of interleukin-6 production
GO:0042104 positive regulation of activated T cell proliferation
GO:0042981 regulation of apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044351 macropinocytosis
GO:0050727 regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090197 positive regulation of chemokine secretion
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR001315 CARD domain
IPR004020 DAPIN domain
IPR011029 Death-like domain
PFAM PF00619
PF02758
PRINTS
PIRSF
SMART SM00114
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MQF6
UniProt Splice Variant
Entrez Gene 282846
UniGene Bt.11586
RefSeq NP_777155
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057919
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca