InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIMS2

Summary

InnateDB Protein

IDBP-69177.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIMS2

Protein Name

LIM and senescent cell antigen-like domains 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000326888

InnateDB Gene

IDBG-69173 (LIMS2)

Protein Structure

UniProt Annotation

Function

Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration. {ECO:0000269PubMed:12167643}.

Subcellular Localization

Nucleus {ECO:0000305}. Cell junction, focal adhesion {ECO:0000269PubMed:12167643}. Cell membrane {ECO:0000269PubMed:12167643}; Peripheral membrane protein {ECO:0000269PubMed:12167643}; Cytoplasmic side {ECO:0000269PubMed:12167643}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding

Biological Process

GO:0016337	single organismal cell-cell adhesion
GO:0034329	cell junction assembly
GO:0043066	negative regulation of apoptotic process
GO:0045216	cell-cell junction organization
GO:0050680	negative regulation of epithelial cell proliferation
GO:2000178	negative regulation of neural precursor cell proliferation
GO:2000346	negative regulation of hepatocyte proliferation
GO:2001046	positive regulation of integrin-mediated signaling pathway