InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: XPNPEP1

Summary

InnateDB Protein

IDBP-691828.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XPNPEP1

Protein Name

Xaa-Pro aminopeptidase 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000052124

InnateDB Gene

IDBG-639638 (XPNPEP1)

Protein Structure

UniProt Annotation

Function

Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0070006	metalloaminopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0010815	bradykinin catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000587 Creatinase, N-terminal
IPR000994 Peptidase M24, structural domain
IPR028980 Creatinase/Aminopeptidase P, N-terminal

PFAM

PF01321
PF00557

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1JPJ2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

513156

UniGene

Bt.88697

RefSeq

NP_001069070

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC133601 BT025361

GenPept

AAI33602 ABF57317