Version 5.4
Bos taurus Protein: PFKL
Summary
InnateDB Protein IDBP-691882.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFKL
Protein Name 6-phosphofructokinase, liver type
Synonyms ATP-PFK; PFK-L;
Species Bos taurus
Ensembl Protein ENSBTAP00000051545
InnateDB Gene IDBG-639689 (PFKL)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0003872 6-phosphofructokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019900 kinase binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0070061 fructose binding
GO:0070095 fructose-6-phosphate binding
Biological Process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
GO:0008152 metabolic process
GO:0009749 response to glucose
GO:0016310 phosphorylation
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0046676 negative regulation of insulin secretion
GO:0046835 carbohydrate phosphorylation
GO:0051259 protein oligomerization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005945 6-phosphofructokinase complex
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000023 Phosphofructokinase domain
IPR009161 6-phosphofructokinase, eukaryotic type
IPR022953 Phosphofructokinase
PFAM PF00365
PRINTS PR00476
PIRSF PIRSF000533
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1A4J1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508683
UniGene Bt.5061
RefSeq NP_001073713
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126578
GenPept AAI26579

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca