InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CCR7

Summary

InnateDB Protein

IDBP-691909.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCR7

Protein Name

C-C chemokine receptor type 7 precursor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000052953

InnateDB Gene

IDBG-639725 (CCR7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0016493	C-C chemokine receptor activity
GO:0035757	chemokine (C-C motif) ligand 19 binding
GO:0035758	chemokine (C-C motif) ligand 21 binding
GO:0038117	C-C motif chemokine 19 receptor activity
GO:0038121	C-C motif chemokine 21 receptor activity

Biological Process

GO:0002408	myeloid dendritic cell chemotaxis
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0002885	positive regulation of hypersensitivity
GO:0002922	positive regulation of humoral immune response
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032649	regulation of interferon-gamma production
GO:0032735	positive regulation of interleukin-12 production
GO:0038115	chemokine (C-C motif) ligand 19 signaling pathway
GO:0038116	chemokine (C-C motif) ligand 21 signaling pathway
GO:0045060	negative thymic T cell selection
GO:0050706	regulation of interleukin-1 beta secretion
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0071345	cellular response to cytokine stimulus
GO:0072610	interleukin-12 secretion
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0097029	mature dendritic cell differentiation
GO:2000510	positive regulation of dendritic cell chemotaxis
GO:2000522	positive regulation of immunological synapse formation
GO:2000525	positive regulation of T cell costimulation
GO:2000526	positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR001718 CC chemokine receptor 7
IPR005383 CC chemokine receptor like 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00657
PR00645
PR00641
PR01558

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite