InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RABGEF1

Summary

InnateDB Protein

IDBP-691975.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RABGEF1

Protein Name

Rab5 GDP/GTP exchange factor

Synonyms

RABEX5;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005011

InnateDB Gene

IDBG-639781 (RABGEF1)

Protein Structure

UniProt Annotation

Function

Rab effector protein acting as linker between gamma- adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. {ECO:0000269PubMed:16462746, ECO:0000269PubMed:9323142}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9323142}. Early endosome {ECO:0000269PubMed:9323142}. Recycling endosome {ECO:0000269PubMed:9323142}.

Disease Associations

Tissue Specificity

Detected in brain. {ECO:0000269PubMed:9323142}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0002686	negative regulation of leukocyte migration
GO:0006810	transport
GO:0006897	endocytosis
GO:0015031	protein transport
GO:0016567	protein ubiquitination
GO:0033004	negative regulation of mast cell activation
GO:0043305	negative regulation of mast cell degranulation
GO:0046580	negative regulation of Ras protein signal transduction
GO:0048261	negative regulation of receptor-mediated endocytosis
GO:0050728	negative regulation of inflammatory response
GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway
GO:1900165	negative regulation of interleukin-6 secretion
GO:1900235	negative regulation of Kit signaling pathway