InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PGLYRP1

Summary

InnateDB Protein

IDBP-691978.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGLYRP1

Protein Name

Peptidoglycan recognition protein 1

Synonyms

PGLYRP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003414

InnateDB Gene

IDBG-639790 (PGLYRP1)

Protein Structure

UniProt Annotation

Function

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast. {ECO:0000269PubMed:11880375, ECO:0000269PubMed:16394004}.

Subcellular Localization

Secreted {ECO:0000269PubMed:16394004}. Cytoplasmic granule {ECO:0000269PubMed:16394004}.

Disease Associations

Tissue Specificity

Synthesized only in bone marrow. The mature protein is stored in the cytoplasmic granules of eosinophils and neutrophils but is absent from monocytes, lymphocytes, or platelets. {ECO:0000269PubMed:11880375}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity
GO:0016019	peptidoglycan receptor activity
GO:0042834	peptidoglycan binding

Biological Process

GO:0002221	pattern recognition receptor signaling pathway
GO:0002376	immune system process
GO:0009253	peptidoglycan catabolic process
GO:0016045	detection of bacterium
GO:0031640	killing of cells of other organism
GO:0032689	negative regulation of interferon-gamma production
GO:0032827	negative regulation of natural killer cell differentiation involved in immune response
GO:0042742	defense response to bacterium
GO:0044117	growth of symbiont in host
GO:0045087	innate immune response
GO:0050728	negative regulation of inflammatory response
GO:0050830	defense response to Gram-positive bacterium
GO:0050832	defense response to fungus

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002502 N-acetylmuramoyl-L-alanine amidase domain
IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria
IPR017331 Peptidoglycan recognition protein, PGRP-S

PFAM

PF01510

PRINTS

PIRSF

PIRSF037945

SMART

SM00644
SM00701

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8SPP7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

282305

UniGene

Bt.9980

RefSeq

NP_776998

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY083309 BC142042 EU746450 EU746451 EU746452 EU746455

GenPept

AAI42043 AAL87002 ACH92779 ACH92780 ACH92781 ACH92784