Version 5.4
Bos taurus Protein: CLEC6A
Summary
InnateDB Protein IDBP-692022.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLEC6A
Protein Name C-type lectin domain family 6 member A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000032279
InnateDB Gene IDBG-639832 (CLEC6A)
Protein Structure
UniProt Annotation
Function Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed at the highest levels in lymph nodes, at moderate levels in skin, small intestine, liver, and lung, and at lower levels in abomasum and spleen, but is not in the brain. Abundantly expressed by Langerhans cells compared to macrophages. {ECO:0000269PubMed:16213030}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030246 carbohydrate binding
Biological Process
GO:0002376 immune system process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0050715 positive regulation of cytokine secretion
GO:0050832 defense response to fungus
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001304 C-type lectin
IPR002353 Type-2 ice-structuring protein
IPR016187 C-type lectin fold
PFAM PF00059
PRINTS PR00356
PIRSF
SMART SM00034
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3LUH2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514979
UniGene Bt.25023
RefSeq NP_001029651
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DQ176046 DQ176047
GenPept ABA08411 ABA08412

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca