InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PDE5A

Summary

InnateDB Protein

IDBP-692053.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE5A

Protein Name

cGMP-specific 3',5'-cyclic phosphodiesterase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000014479

InnateDB Gene

IDBG-639844 (PDE5A)

Protein Structure

UniProt Annotation

Function

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP. {ECO:0000269PubMed:8530505}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0004112	cyclic-nucleotide phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0030553	cGMP binding
GO:0046872	metal ion binding
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity

Biological Process

GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0042130	negative regulation of T cell proliferation
GO:0043406	positive regulation of MAP kinase activity
GO:0046068	cGMP metabolic process
GO:0046069	cGMP catabolic process
GO:0055118	negative regulation of cardiac muscle contraction
GO:0055119	relaxation of cardiac muscle
GO:0060282	positive regulation of oocyte development

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003018 GAF domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase
IPR029016 GAF domain-like

PFAM

PF00233
PF01590
PF13185
PF13492

PRINTS

PR00387

PIRSF

SMART

SM00065
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q28156

PhosphoSite

PhosphoSite-Q28156

TrEMBL

UniProt Splice Variant

Entrez Gene

281972

UniGene

Bt.540

RefSeq

NP_776842

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

L16545

GenPept

AAB00990