InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MYOZ2

Summary

InnateDB Protein

IDBP-692071.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYOZ2

Protein Name

Myozenin-2

Synonyms

CS-1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003330

InnateDB Gene

IDBG-639877 (MYOZ2)

Protein Structure

UniProt Annotation

Function

Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Colocalizes with ACTN1 and PPP3CA at the Z- line of heart and skeletal muscle. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0031433	telethonin binding

Biological Process

Cellular Component

GO:0005737	cytoplasm
GO:0015629	actin cytoskeleton
GO:0030018	Z disc

Protein Structure and Domains

PDB ID

InterPro

IPR008438 Myozenin

PFAM

PF05556

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5E9V3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

540487

UniGene

RefSeq

NP_001015676

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103121 BT020817

GenPept

AAI03122 AAX08834