InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PDXK

Summary

InnateDB Protein

IDBP-692098.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDXK

Protein Name

Pyridoxal kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000024203

InnateDB Gene

IDBG-639897 (PDXK)

Protein Structure

UniProt Annotation

Function

Required for synthesis of pyridoxal-5-phosphate from vitamin B6. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0008478	pyridoxal kinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0030170	pyridoxal phosphate binding
GO:0030955	potassium ion binding
GO:0031402	sodium ion binding
GO:0031403	lithium ion binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0008283	cell proliferation
GO:0009443	pyridoxal 5'-phosphate salvage
GO:0016310	phosphorylation
GO:0042823	pyridoxal phosphate biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004625 Pyridoxal phosphate (active vitamin B6) biosynthesis, pyridoxal kinase
IPR011611 Carbohydrate kinase PfkB
IPR013749 Pyridoxamine kinase/Phosphomethylpyrimidine kinase
IPR029056 Ribokinase-like

PFAM

PF00294
PF08543

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0II59

PhosphoSite