InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ABL1

Summary

InnateDB Protein

IDBP-692170.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABL1

Protein Name

c-abl oncogene 1, non-receptor tyrosine kinase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023920

InnateDB Gene

IDBG-639939 (ABL1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 278 interaction(s) predicted by orthology.

Predicted by orthology
Total	278 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017124	SH3 domain binding
GO:0019904	protein domain specific binding
GO:0019905	syntaxin binding
GO:0030145	manganese ion binding
GO:0051019	mitogen-activated protein kinase binding
GO:0070064	proline-rich region binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0006975	DNA damage induced protein phosphorylation
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030036	actin cytoskeleton organization
GO:0042770	signal transduction in response to DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051353	positive regulation of oxidoreductase activity
GO:0051726	regulation of cell cycle
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:2001020	regulation of response to DNA damage stimulus

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0031252	cell leading edge
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR015015 F-actin binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM