Version 5.4
Bos taurus Protein: AFAP1L2
Summary
InnateDB Protein IDBP-692215.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AFAP1L2
Protein Name Actin filament-associated protein 1-like 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006439
InnateDB Gene IDBG-640002 (AFAP1L2)
Protein Structure
UniProt Annotation
Function May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0017124 SH3 domain binding
GO:0030296 protein tyrosine kinase activator activity
GO:0042169 SH2 domain binding
Biological Process
GO:0006954 inflammatory response
GO:0007346 regulation of mitotic cell cycle
GO:0032675 regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
GO:0061098 positive regulation of protein tyrosine kinase activity
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q17R10
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 615436
UniGene Bt.22165
RefSeq NP_001069843
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118084
GenPept AAI18085

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca