InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: WBSCR22

Summary

InnateDB Protein

IDBP-692248.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WBSCR22

Protein Name

Uncharacterized methyltransferase WBSCR22

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022697

InnateDB Gene

IDBG-640042 (WBSCR22)

Protein Structure

UniProt Annotation

Function

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus- specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Localized diffusely throughout the nucleus and the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006364	rRNA processing
GO:0008152	metabolic process
GO:0016568	chromatin modification
GO:0032259	methylation
GO:0042254	ribosome biogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR013216 Methyltransferase type 11
IPR022238 Uncharacterised protein family, methyltransferase, Williams-Beuren syndrome
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF08241
PF12589

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q58DP0

PhosphoSite