Version 5.4
Bos taurus Protein: PHB2
Summary
InnateDB Protein IDBP-692359.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHB2
Protein Name Prohibitin-2
Synonyms REA;
Species Bos taurus
Ensembl Protein ENSBTAP00000017442
InnateDB Gene IDBG-640131 (PHB2)
Protein Structure
UniProt Annotation
Function Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Also cytoplasmic and nuclear. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.
Predicted by orthology
Total 75 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060744 mammary gland branching involved in thelarche
GO:0060749 mammary gland alveolus development
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000163 Prohibitin
IPR001107 Band 7 protein
PFAM PF01145
PRINTS PR00679
PIRSF
SMART SM00244
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2HJ97
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 515363
UniGene Bt.59547
RefSeq NP_001039663
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC113241
GenPept AAI13242

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca