Version 5.4
Bos taurus Protein: TIFA
Summary
InnateDB Protein IDBP-692384.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIFA
Protein Name TRAF-interacting protein with FHA domain-containing protein A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000046244
InnateDB Gene IDBG-640158 (TIFA)
Protein Structure
UniProt Annotation
Function Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (By similarity). {ECO:0000250UniProtKB:Q793I8, ECO:0000250UniProtKB:Q96CG3}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000253 Forkhead-associated (FHA) domain
PFAM PF00498
PRINTS
PIRSF
SMART SM00240
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2VDM0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 783855
UniGene Bt.29044
RefSeq NP_001075090
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133302
GenPept AAI33303

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca