Version 5.4
Homo sapiens Protein: EVPL
Summary
InnateDB Protein IDBP-69239.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EVPL
Protein Name envoplakin
Synonyms EVPK;
Species Homo sapiens
Ensembl Protein ENSP00000301607
InnateDB Gene IDBG-69237 (EVPL)
Protein Structure
UniProt Annotation
Function Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.
Subcellular Localization Cell junction, desmosome. Cornified envelope. Cytoplasm, cytoskeleton. Note=Colocalized with DSP at desmosomes and along intermediate filaments.
Disease Associations
Tissue Specificity Exclusively expressed in stratified squamous epithelia.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0030674 protein binding, bridging
Biological Process
GO:0008544 epidermis development
GO:0018149 peptide cross-linking
GO:0030216 keratinocyte differentiation
GO:0031424 keratinization
Cellular Component
GO:0001533 cornified envelope
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0030057 desmosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001101 Plectin repeat
IPR009078 Ferritin-like superfamily
IPR018159 Spectrin/alpha-actinin
PFAM PF00681
PRINTS
PIRSF
SMART SM00250
SM00150
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92817
PhosphoSite PhosphoSite-Q92817
TrEMBL K7EQ87
UniProt Splice Variant
Entrez Gene 2125
UniGene Hs.500635
RefSeq NP_001979
HUGO HGNC:3503
OMIM 601590
CCDS CCDS11737
HPRD 03352
IMGT
EMBL AC040980 BC126103 BC126105 U53786 U72843 U72845 U72846 U72847 U72848 U72849
GenPept AAC64662 AAD00186 AAI26104 AAI26106

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca