InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RAB5C

Summary

InnateDB Protein

IDBP-692390.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB5C

Protein Name

Ras-related protein Rab-5C

Synonyms

RAB5B;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015581

InnateDB Gene

IDBG-640162 (RAB5C)

Protein Structure

UniProt Annotation

Function

Protein transport. Probably involved in vesicular traffic (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007032	endosome organization
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0030100	regulation of endocytosis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005811	lipid particle
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030139	endocytic vesicle
GO:0031901	early endosome membrane
GO:0042470	melanosome
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF04670
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q58DS9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

613749

UniGene

Bt.5451

RefSeq

NP_001029915

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC118226 BT021518

GenPept

AAI18227 AAX46365