Version 5.4
Bos taurus Protein: HCRT
Summary
InnateDB Protein IDBP-692396.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCRT
Protein Name Orexin-A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000875
InnateDB Gene IDBG-640171 (HCRT)
Protein Structure
UniProt Annotation
Function Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity). {ECO:0000250}.
Subcellular Localization Rough endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007218 neuropeptide signaling pathway
GO:0007631 feeding behavior
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001704 Prepro-orexin
PFAM PF02072
PRINTS PR01091
PIRSF PIRSF037824
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P56717
PhosphoSite PhosphoSite-
TrEMBL Q8MKI6
UniProt Splice Variant
Entrez Gene 281222
UniGene Bt.13040
RefSeq NP_001159992
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB084625 DAAA02049183
GenPept BAB91446

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca