Version 5.4
Bos taurus Protein: UPK3B
Summary
InnateDB Protein IDBP-692403.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UPK3B
Protein Name Uroplakin-3b
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000041883
InnateDB Gene IDBG-640173 (UPK3B)
Protein Structure
UniProt Annotation
Function Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000269PubMed:12446744}.
Disease Associations
Tissue Specificity Expression is urothelium-specific. {ECO:0000269PubMed:12446744}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0010629 negative regulation of gene expression
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q864V4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282115
UniGene Bt.22858
RefSeq NP_001012690
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY233461
GenPept AAO89506

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca