Version 5.4
Bos taurus Protein: STAT5A
Summary
InnateDB Protein IDBP-692423.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAT5A
Protein Name signal transducer and activator of transcription 5A
Synonyms STAT5A/MGF; STATA5;
Species Bos taurus
Ensembl Protein ENSBTAP00000034715
InnateDB Gene IDBG-640187 (STAT5A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0000255 allantoin metabolic process
GO:0001553 luteinization
GO:0001779 natural killer cell differentiation
GO:0006101 citrate metabolic process
GO:0006103 2-oxoglutarate metabolic process
GO:0006105 succinate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006549 isoleucine metabolic process
GO:0006573 valine metabolic process
GO:0006600 creatine metabolic process
GO:0006631 fatty acid metabolic process
GO:0007165 signal transduction
GO:0007259 JAK-STAT cascade
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0008284 positive regulation of cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019218 regulation of steroid metabolic process
GO:0019221 cytokine-mediated signaling pathway
GO:0019530 taurine metabolic process
GO:0019915 lipid storage
GO:0030155 regulation of cell adhesion
GO:0030856 regulation of epithelial cell differentiation
GO:0030879 mammary gland development
GO:0032825 positive regulation of natural killer cell differentiation
GO:0033026 negative regulation of mast cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0038161 prolactin signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042104 positive regulation of activated T cell proliferation
GO:0043029 T cell homeostasis
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045579 positive regulation of B cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045647 negative regulation of erythrocyte differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046449 creatinine metabolic process
GO:0046543 development of secondary female sexual characteristics
GO:0046544 development of secondary male sexual characteristics
GO:0048541 Peyer's patch development
GO:0050729 positive regulation of inflammatory response
GO:0060376 positive regulation of mast cell differentiation
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060740 prostate gland epithelium morphogenesis
GO:0060742 epithelial cell differentiation involved in prostate gland development
GO:0061180 mammary gland epithelium development
GO:0070668 positive regulation of mast cell proliferation
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil
PFAM PF00017
PF14633
PF02865
PF01017
PF02864
PRINTS PR00401
PIRSF
SMART SM00252
SM00964
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q6VLX0
UniProt Splice Variant
Entrez Gene 282375
UniGene Bt.4641
RefSeq NP_001012691
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY339394 AY484401 AY961373 AY961374 DAAA02049185 DAAA02049186
GenPept AAR11219 AAR24093 AAX63480 AAX63481

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca