InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PRKRA

Summary

InnateDB Protein

IDBP-692437.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKRA

Protein Name

Interferon-inducible double stranded RNA-dependent protein kinase activator A

Synonyms

PACT;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001451

InnateDB Gene

IDBG-640208 (PRKRA)

Protein Structure

UniProt Annotation

Function

Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0016310	phosphorylation
GO:0030422	production of siRNA involved in RNA interference
GO:0031047	gene silencing by RNA
GO:0034599	cellular response to oxidative stress
GO:0042473	outer ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0048705	skeletal system morphogenesis
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway