Version 5.4
Bos taurus Protein: BCAT2
Summary
InnateDB Protein IDBP-692538.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCAT2
Protein Name Branched-chain-amino-acid aminotransferase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000031858
InnateDB Gene IDBG-640286 (BCAT2)
Protein Structure
UniProt Annotation
Function Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004084 branched-chain-amino-acid transaminase activity
GO:0008483 transaminase activity
GO:0016740 transferase activity
GO:0052654 L-leucine transaminase activity
GO:0052655 L-valine transaminase activity
GO:0052656 L-isoleucine transaminase activity
Biological Process
GO:0006549 isoleucine metabolic process
GO:0006550 isoleucine catabolic process
GO:0006551 leucine metabolic process
GO:0006573 valine metabolic process
GO:0008152 metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0009081 branched-chain amino acid metabolic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009083 branched-chain amino acid catabolic process
GO:0010817 regulation of hormone levels
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR001544 Aminotransferase, class IV
IPR005786 Branched-chain amino acid aminotransferase II
PFAM PF01063
PRINTS
PIRSF PIRSF006468
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5EA40
PhosphoSite PhosphoSite-
TrEMBL Q0V8J6
UniProt Splice Variant
Entrez Gene 281643
UniGene Bt.9004
RefSeq NP_001013611
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114055 BT020729 BT021163 BT026175 BT026222
GenPept AAI14056 AAX08746 AAX31345 ABG67014 ABG67061

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca