InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ZNHIT1

Summary

InnateDB Protein

IDBP-692624.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNHIT1

Protein Name

Zinc finger HIT domain-containing protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000448

InnateDB Gene

IDBG-640366 (ZNHIT1)

Protein Structure

UniProt Annotation

Function

Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0042826	histone deacetylase binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0031063	regulation of histone deacetylation
GO:0042129	regulation of T cell proliferation
GO:0070317	negative regulation of G0 to G1 transition

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR007529 Zinc finger, HIT-type

PFAM

PF04438

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q24JY4

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

514997

UniGene

Bt.15946

RefSeq

NP_001039650

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC114191

GenPept

AAI14192